W.H.O.I. CTD MicroVAX II Data Acquisition System : part II. Operator’s guide

AQUI89 is a real-time shipboard Conductivity Temperature Depth profiler (CTD) data acquisition system used at the Woods Hole Oceanographic Institution to collect, preview and store (log) data from the WHOI/Brown Mark III CTD microprofiler on a MicroVAX II computer, running the VAX/VMS operating system, version 5.3. This manual contains the instructions for operation of the AQUI89 data acquisition system version 1.0.Funding was provided by the National Science Foundation under Grant Nos. OCE87-12087 and OCE90-05218

W.H.O.I. CTD MicroVAX II Data Acquisition System : part I, installation manual

AQUI89 is a real-time shipboard Conductivity Temperature Depth profiler (CTD) data acquisition system used at the Woods Hole Oceanographic Institution to collect, preview and store (log) data from the WHOI/Brown Mark III CTD microprofiler on a MicroVAX II computer, running the VAX/VMS operating system, version 5.3. This manual contains the instructions for the installation of the AQUI89 data acquisition system version 1.0.Funding was provided by the National Science Foundation under Grant Nos. OCE87-12087 and OCE90-05218

Calculation of 3-dimensional synthetic seismograms on the connection machine

A three dimensional, second order finite difference method was used to create synthetic seismograms for elastic wave propagation in heterogeneous media. These synthetic seismograms are used to model rough seafloor, the shallow crust, or complex structural and stratigraphic settings with strong lateral heterogeneities. The finite difference method is preferred because it allows models of any complexity to be generated and includes all multiple scattering, wave conversion and diffraction effects. The method uses a fully staggered grid as developed by Virieux (1986). Wavefront snapshots and time series output allow the scattering and focussing of different wave modes with direction to be visualized. The extensive calculations required for realistic size models stretches the resources of serial computers like the VAX 8800. On the Connection Machine, a massively parallel computer, the finite difference grid can be directly mapped onto the virtual processors, reducing the nested time and space loops in the serial code to a single time loop. As a result, the computation time is reduced dramatically.Funding provided by Office of Naval Research under Contract Numbers: N00014-87-K-0007 and N00014-89-J-1012

Benchmarking the two-dimensional finite difference synthetic seismogram code

During the past six months, the two-dimensional finite difference synthetic seismogram code was installed and run on a number of different computer systems. The results were compared for timing, accuracy and the ease with which the code was adapted to each system. This report documents the software modifications and the method used to implement the finite difference code on each computer, and presents the results of the benchmark survey.Funding was provided by the Office of Naval Research under Contract No. N00014-89-J-1012

The Effect of Partisan Representation at Different Levels of Government on Satisfaction with Democracy in the United States

In this paper, we analyze how variations in partisan representation across different levels of government influence Americans’ satisfaction with the democracy in the United States. We conduct two survey experiments and analyze data from the 2016 American National Election Study postelection survey. We find that Americans are the most satisfied with democracy when their most preferred party controls both the federal and their respective state governments. However, we also find that even if an individual’s least preferred party only controls one level of government, they are still more satisfied with democracy than if their most preferred party controls no levels of government. These findings suggest that competition in elections across both the national and state government, where winning and losing alternates between the two parties, may have positive outcomes for attitudes toward democracy

The phenome-wide distribution of genetic variance

A general observation emerging from estimates of additive genetic variance in sets of functionally or developmentally related traits is that much of the genetic variance is restricted to few trait combinations as a consequence of genetic covariance among traits. While this biased distribution of genetic variance among functionally related traits is now well documented, how it translates to the broader phenome and therefore any trait combination under selection in a given environment is unknown. We show that 8,750 gene expression traits measured in adult male Drosophila serrata exhibit widespread genetic covariance among random sets of five traits, implying that pleiotropy is common. Ultimately, to understand the phenome-wide distribution of genetic variance, very large additive genetic variance-covariance matrices (G) are required to be estimated. We draw upon recent advances in matrix theory for completing high-dimensional matrices to estimate the 8,750-trait G and show that large numbers of gene expression traits genetically covary as a consequence of a single genetic factor. Using gene ontology term enrichment analysis, we show that the major axis of genetic variance among expression traits successfully identified genetic covariance among genes involved in multiple modes of transcriptional regulation. Our approach provides a practical empirical framework for the genetic analysis of high-dimensional phenome-wide trait sets and for the investigation of the extent of high-dimensional genetic constraint

Social comparisons and organizational support : implications for commitment and retention

Organizational support theory (OST) suggests that employees develop a general perception of the extent to which the organization values their contributions and cares about their well-being (perceived organizational support – POS), and respond to that support through attitudes and behaviors that are beneficial toward the organization. Although OST emphasizes both social exchange and self-enhancement processes, most accounts of POS’s effects are rooted in social exchange. For example, POS’s linkages with commitment and retention have been explained as an exchange of support for positive attitudes and continued employment. This research sheds light on self-enhancement’s less-understood role in fostering these reactions by demonstrating the influence of social comparison effects. Drawing on a sample of 342 employees nested in 82 work-units of a US hospitality company, our analysis demonstrates that favorable POS comparisons with peers in one’s work-unit are positively associated with commitment and retention, whereas unfavorable comparisons are negatively related. Results also show that comparisons taking place in less-supported work-units have stronger impact than comparisons made in those with better support. Our findings extend OST by revealing the importance of social comparisons in engendering responses to organizational support, and in so doing potentially explicate the differential ways social exchange and self-enhancement operate with regard to POS

Evolutionary history of mammalian sucking lice (Phthiraptera: Anoplura)

<p>Abstract</p> <p>Background</p> <p>Sucking lice (Phthiraptera: Anoplura) are obligate, permanent ectoparasites of eutherian mammals, parasitizing members of 12 of the 29 recognized mammalian orders and approximately 20% of all mammalian species. These host specific, blood-sucking insects are morphologically adapted for life on mammals: they are wingless, dorso-ventrally flattened, possess tibio-tarsal claws for clinging to host hair, and have piercing mouthparts for feeding. Although there are more than 540 described species of Anoplura and despite the potential economical and medical implications of sucking louse infestations, this study represents the first attempt to examine higher-level anopluran relationships using molecular data. In this study, we use molecular data to reconstruct the evolutionary history of 65 sucking louse taxa with phylogenetic analyses and compare the results to findings based on morphological data. We also estimate divergence times among anopluran taxa and compare our results to host (mammal) relationships.</p> <p>Results</p> <p>This study represents the first phylogenetic hypothesis of sucking louse relationships using molecular data and we find significant conflict between phylogenies constructed using molecular and morphological data. We also find that multiple families and genera of sucking lice are not monophyletic and that extensive taxonomic revision will be necessary for this group. Based on our divergence dating analyses, sucking lice diversified in the late Cretaceous, approximately 77 Ma, and soon after the Cretaceous-Paleogene boundary (ca. 65 Ma) these lice proliferated rapidly to parasitize multiple mammalian orders and families.</p> <p>Conclusions</p> <p>The diversification time of sucking lice approximately 77 Ma is in agreement with mammalian evolutionary history: all modern mammal orders are hypothesized to have diverged by 75 Ma thus providing suitable habitat for the colonization and radiation of sucking lice. Despite the concordant timing of diversification events early in the association between anoplurans and mammals, there is substantial conflict between the host and parasite phylogenies. This conflict is likely the result of a complex history of host switching and extinction events that occurred throughout the evolutionary association between sucking lice and their mammalian hosts. It is unlikely that there are any ectoparasite groups (including lice) that tracked the early and rapid radiation of eutherian mammals.</p

Phase I/II Study of Bortezomib-BEAM and Autologous Hematopoietic Stem Cell Transplantation for Relapsed Indolent Non-Hodgkin Lymphoma, Transformed, or Mantle Cell Lymphoma

AbstractA phase I/II trial was designed to evaluate the safety and efficacy of adding bortezomib to standard BEAM (BCNU, etoposide, cytarabine, melphalan) and autologous hematopoietic stem cell transplantation (ASCT). Eligible patients had relapsed/refractory indolent or transformed non-Hodgkin lymphoma or mantle cell lymphoma (MCL) that was relapsed/refractory or in first partial (PR) or complete remission (CR). Patients received bortezomib on days −11, −8, −5, and −2 before ASCT. Phase I had 4 dose cohorts (.8, 1, 1.3, and 1.5 mg/m2) and 3 patients were accrued to each. Any nonhematological ASCT-related toxicity >2 on the Bearman scale occurring between day −11 and engraftment defined the maximum tolerated dose (MTD). After the MTD has been reached, another 20 patients were enrolled at this dose to determine a preliminary overall response rate (ORR). Patients who were in CR or PR at day +100 were considered responders. The study enrolled 42 patients through August 14, 2009. The median age was 58 (range, 34 to 73) years, with 33 males and 9 females. The most common diagnoses were MCL (23 patients) and follicular lymphoma (7 patients). The median number of prior therapies was 1 (range, 0 to 6). The median follow-up was 4.88 (range, 1.07 to 6.98) years. Thirteen patients were treated in phase I and 29 patients were treated in phase II. The MTD was initially determined to be 1.5 mg/m2 but it was later decreased to 1 mg/m2 because of excessive gastrointestinal toxicity and peripheral neuropathy. The ORR was 95% at 100 days and 87% at 1 year. For all 38 evaluable patients at 1 year, responses were CR 84%, PR 1%, and progressive disease 13%. Progression-free survival (PFS) was 83% (95% CI, 68% to 92%) at 1 year, and 32% (15% to 51%) at 5 years. Overall survival (OS) was 91% (95% CI, 79% to 96%) at 1 year and 67% (50% to 79%) at 5 years. The most common National Cancer Institute grade 3 toxicities were neutropenic fever (59%), anorexia (21%), peripheral neuropathy (19%), orthostatic hypotension/vasovagal syncope (16%), and 1 patient failed to engraft. Compared with 26 MCL in CR1 historic controls treated with BEAM and ASCT, PFS was 85% and 43% for the BEAM group versus 87% and 57% for those who received bortezomib in addition to standard BEAM (V-BEAM) at 1 and 5 years, respectively (log-rank P = .37). OS was 88% and 50% for the BEAM group versus 96% and 72% for V-BEAM at 1 and 5 years, respectively (log-rank P = .78). In conclusion, V-BEAM and ASCT is feasible. The toxicities were manageable and we did not observe any treatment-related mortalities; however, we did observe an excess of autonomic dysfunction and ileus, which is concerning for overlapping toxicity with BEAM conditioning. Determining relative efficacy of V-BEAM compared to BEAM would require a randomized trial